Tidomet/Tidomet CR Special Precautions

Patients receiving levodopa alone must discontinue medication at least 8 hours before Tidomet is started. Tidomet should be substituted at a dosage that will provide approximately 25% of the previous levodopa dosage. Patients who are taking Tidomet should be instructed not to take additional levodopa unless prescribed by the physician. As with levodopa, Tidomet may cause involuntary movements and mental disturbances. All patients taking Tidomet should be observed carefully for the development of depression with concomitant suicidal tendencies. Tidomet should be administered cautiously to patients with severe cardiovascular or pulmonary disease, bronchial asthma, renal hepatic or endocrine disease, past or current psychosis.
Use in children: Safety in patients under 18 years of age has not been established.
Use in pregnancy & lactation: Tidomet must be used in women of child-bearing age group after weighing the possible hazards to the mother and the child. Tidomet should not be given to nursing mothers.